Gold nanoparticles coated with polyelectrolytes and use...

Details Gold nanoparticles coated with polyelectrolytes and use... Gold nanoparticles coated with polyelectrolytes and use...

A - Human Necessities

61

K

A61K 9/51 (2006.01)

Patent

CA 2742915

It is described a gold nanoparticle coated with from two to five layers of a combination of a polyelectrolyte having amino functionality and a polyelectrolyte having sulfonic functionality, or with one single layer of said polyelectrolyte having amino functionality, preferably polyallylamine, or sulfonic functionality, preferably polystyrenesulfonic, characterized in that said nanoparticle comprises an outer layer of albumin. It is also described the process for its preparation, its use as carriers intended to cross blood-brain barrier and its use as medicament, in particular for treatment of neurodegenerative diseases, more in particular of diseases caused by protein aggregates, such as prion diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. Also described are pharmaceutical compositions comprising said nanoparticle. Image

L'invention porte sur une nanoparticule d'or revêtue de deux à cinq couches d'une combinaison de polyélectrolyte à fonctionnalité amino et de polyélectrolyte à fonctionnalité sulfonique, ou revêtue d'une seule couche dudit polyélectrolyte à fonctionnalité amino, de préférence polyallylamine, ou à fonctionnalité sulfonique, de préférence polystyrène sulfonique, caractérisée en ce que ladite nanoparticule comprend une couche externe d'albumine. L'invention porte également sur son procédé de préparation, sur son utilisation en tant que supports destinés à traverser la barrière hémato-encéphalique et sur son utilisation en tant que médicament, en particulier pour le traitement de maladies neurodégénératives, plus particulièrement de maladies provoquées par des agrégats protéiques, telles que les maladies du prion, la maladie d'Alzheimer, la maladie de Parkinson, la maladie d'Huntington et la sclérose latérale amyotrophique; l'invention porte également sur des compositions pharmaceutiques comprenant ladite nanoparticule.

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