Specific removal of ldl from blood

Details Specific removal of ldl from blood Specific removal of ldl from blood

C - Chemistry, Metallurgy

07

K

167/114, 260/222

C07K 16/18 (2006.01) A61K 35/14 (2006.01) A61M 1/36 (2006.01) C07K 1/22 (2006.01) C07K 17/10 (2006.01)

Patent

CA 2001358

-32- Abstract Disclosed herein are particularly efficient methods to reduce cholesterol in patients by treating whole blood with agarose beads conjugated to anti-LDL antibodies or, especially when conjugated through the mediation of an amino functionality, to a polyanionic sulfate. In preferred embodiments, the beads are characterized as comprising 0.5-3% agarose, preferably 2% agarose, and having diameters of 200-300 micron. Preferred antibodies are cross-reactive with C3D1 anti- bodies.

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