Oral pharmaceutical composition of a poorly water-soluble...

A - Human Necessities – 61 – K

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A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/55 (2006.01) A61K 45/08 (2006.01)

Patent

CA 2654111

The invention is related to an oral composition of Benzazepin-1-acetic acid derivatives comprising a) said active compound in an amount of between 10 and 65% of the total weight of the formulation; b) at least 10% w/w an alkaline compound or a mixture of alkaline compounds; c) optionally comprises auxiliary materials an amount of between 1% and 45% of the total weight of the formulation. The invention is further related to the above defined oral composition comprising sodium carbonate with a specific particle size and/or surface area as alkaline compound.

La présente invention concerne une composition orale de dérivés d'acide benzazépin-1-acétique comprenant a) ledit composé actif en une quantité comprise entre 10 et 65 % du poids total de la formulation ; b) au moins 10 % m/m d'un composé alcalin ou un mélange de composés alcalins ; c) facultativement des matériaux auxiliaires en une quantité comprise entre 1 % et 45 % du poids total de la formulation. L'invention concerne en outre la composition orale définie ci-dessus comprenant du carbonate de sodium ayant une taille de particule et/ou une surface spécifiques en tant que composé alcalin.

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