Combination of a gaba-a alpha 5 inverse agonist and cox-2...

Details Combination of a gaba-a alpha 5 inverse agonist and cox-2... Combination of a gaba-a alpha 5 inverse agonist and cox-2...

A - Human Necessities

61

K

A61K 45/06 (2006.01)

Patent

CA 2351057

Combinations of a GABAA alpha 5 inverse agonist and a COX-2 inhibitor, NSAID, estrogen or vitamin E are disclosed for treating neurodegenerative conditions such as Alzheimer's Disease.

L'invention se rapporte à des combinaisons d'un agoniste inverse de GABA¿A? .alpha.¿5? et d'un inhibiteur de COX-2, d'un anti-inflammatoire non stéroïdien (NSAID), d'un oestrogène et de vitamine E. Ces combinaisons s'avèrent utiles pour traiter des troubles neurodégénératifs tels que la maladie d'Alzheimer.

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