A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 15/32 (2006.01) A61K 31/721 (2006.01) A61K 38/39 (2006.01) A61L 15/44 (2006.01) A61L 31/00 (2006.01) A61L 33/00 (2006.01) A61P 15/02 (2006.01)
Patent
CA 2337051
The present invention provides a method of stimulating vascularization at a site in a mammal, said method comprising contacting said site with a matrix comprising gelatin and a nitric oxide inhibitor. The gelatin is preferably denatured collagen: The nitric oxide inhibitor may be a sulfonated moiety. The inhibitor may be an L-arginine analog, such as aminoguanidine, N-monoethyl, L-arginine, N-nitro-L-arginine and D-arginine. The matrix may further comprise a nitric oxide scavenger, such as dextran, heparin, cysteine and cystine.
L'invention concerne un procédé permettant de stimuler la vascularisation sur un site donné chez un mammifère, qui consiste à mettre en contact le site considéré avec une matrice comprenant de la gélatine et un inhibiteur d'oxyde nitrique. De préférence, la gélatine est du collagène dénaturé. L'inhibiteur en question peut être une fraction sulfonée. Il peut s'agir d'un analogue de L-arginine, du type aminoguanidine, N-monoéthyle-L-arginine, N-nitro-L-arginine et D-arginine. La matrice peut aussi renfermer un capteur d'oxyde nitrique, du type dextrane, héparine, cystéine et cystine.
Encelle Inc.
Smart & Biggar
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