Human secreted proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2442710

The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diabetes mellitus and/or conditions related to diabetes. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

L'invention porte sur des polypeptides humains sécrétés, sur des molécules d'acide nucléique isolées codant pour lesdits polypeptides qui sont utiles pour diagnostiquer et traiter le diabète sucré et/ou des états liés au diabète, sur des anticorps se fixant auxdits polypeptides, sur des vecteurs, cellules hôtes et produits de recombinaison, sur des procédés de synthèse permettant d'obtenir lesdits polynucléotides, polypeptides, et/ou anticorps, sur des procédés de criblage permettant d'identifier les agonistes et antagonistes des polynucléotides et polypeptides de l'invention, et sur des méthodes et compositions inhibant ou favorisant la production et les fonctions des polypeptides de l'invention.

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