Monoclonal antibodies specific for phf-tau, hybridomas...

Details Monoclonal antibodies specific for phf-tau, hybridomas... Monoclonal antibodies specific for phf-tau, hybridomas...

C - Chemistry, Metallurgy

12

N

C12N 5/20 (2006.01) C07K 7/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01) G01N 33/554 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2178212

The present invention relates more particularly to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to abnormally phosphorylated tau (PHF-tau) residing in the region spanning positions (143-254), and with said monoclonal antibody being characterized by the fact that it is capable of specifically detecting abnormally phosphorylated tau protein (PHF-tau) in cerebrospinal fluid (CSF).

La présente invention se rapporte plus particulièrement à un anticorps monoclonal qui forme un complexe immunologique avec un déterminant antigénique phosphorylaté d'un antigène appartenant à une protéine tau anormalement phosphorylatée (PHF-tau) résidant dans les régions couvrant les positions (143-254). Ledit anticorps monoclonal est caractérisé en ce qu'il est capable de détecter spécifiquement la protéine tau anormalement phosphorylatée dans du liquide céphalo-rachidien.

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