Nitrogen-containing heterocyclic compounds

Details Nitrogen-containing heterocyclic compounds Nitrogen-containing heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/4155 (2006.01) A61K 31/416 (2006.01) A61K 31/4162 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 13/12 (2006.01) A61P 29/00 (2006.01) A61P 29/02 (2006.01) A61P 43/00 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01) C07D 417/08 (2006.01) C07D 417/14 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2728095

Nitrogen-containing heterocyclic compounds represented by the following Formula (1) are provided. The compounds or salts thereof have a strong EP1 antagonistic activity when they are administered to a human or an animal, and they are useful as an effective component of a pharmaceutical agent for prophylaxis and/or treatment of an overactive bladder, for example. Furthermore, they are useful as an effective component of a pharmaceutical agent for the prophylaxis and/or treatment of symptoms including frequent urination, urinary urgency and urinary incontinence. Image 251

L'invention concerne un composé hétérocyclique azoté représenté par la formule générale (1). Le composé ou un sel correspondant présente une puissante activité antagoniste sur un récepteur EP 1, lorsqu'il est administré à un être humain ou à un animal. Par conséquent, le composé ou un sel correspondant est utile, par exemple, en tant qu'ingrédient actif d'un agent pharmaceutique destiné à prévenir et/ou à traiter une vessie hyperactive. Le composé ou un sel correspondant est également utile en tant qu'ingrédient actif d'un agent pharmaceutique destiné à prévenir et/ou à traiter un symptôme tel que les mictions fréquentes, l'urgence urinaire ou l'incontinence urinaire.

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