Dihydrobenzofuran compounds useful as anti-inflammatory agents

Details Dihydrobenzofuran compounds useful as anti-inflammatory agents Dihydrobenzofuran compounds useful as anti-inflammatory agents

C - Chemistry, Metallurgy

07

D

C07D 307/79 (2006.01) A61K 31/33 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) C07D 307/94 (2006.01) C07D 311/58 (2006.01) C07D 313/08 (2006.01) C07D 333/54 (2006.01) C07D 405/00 (2006.01) C07D 405/06 (2006.01) C07D 407/00 (2006.01) C07D 409/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2244196

A compound having structure (I) wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from about 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from 3 to about 7 atoms; (d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (e) W is hydrogen or straight, branched or cyclic alkyl, aryl, hydroxy or alkoxy; and (f) R1 and R2 are independently hydrogen or straight, branched or cyclic alkyl having from one to 10 carbons, aryl, heterocyclyl, heteroaryl, hydroxy, or alkoxy; or R1 and R2 are bonded together to form a ring having from 3 to about 7 atoms wherein one to three atoms may be heteroatoms. Pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.

L'invention concerne un composé ayant la structure (I) dans laquelle (a) n vaut environ de 1 à environ 3; (b) X est sélectionné dans le groupe constitué par O, S, SO ou SO¿2?; (c) Y représente indépendamment hydrogène ou alkyle droit, ramifié ou cyclique possédant de 1 à environ 4 atomes de carbone, ou bien les Y sont liés afin de former un noyau alcanyle possédant de 3 à environ 7 atomes; (d) Z représente hydrogène ou alkyle droit, ramifié ou cyclique possédant de 3 à environ 10 atomes autres que l'hydrogène; (e) W représente hydrogène ou alkyle droit, ramifié ou cyclique, aryle, hydroxy ou alcoxy; et (f) R¿1? et R¿2? représentent indépendamment hydrogène ou alkyle droit, ramifié ou cyclique possédant de 1 à 10 atomes de carbone, aryle, hétérocyclyle, hétéroaryle, hydroxy ou alcoxy; ou R¿1? et R¿2? sont liés afin de former un noyau possédant de 3 à environ 7 atomes, 1 à 3 atomes pouvant être des hétéroatomes. L'invention concerne également des compositions pharmaceutiques comprenant ces composés ainsi que des procédés de traitement de l'inflammation ou de la douleur au moyen de ces composés.

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