C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/80 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2469730
The subject invention pertains to novel compounds (and salts thereof), and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns methods of making the novel compounds. The novel compounds are rapidly metabolized analogs of amiodarone, having the distinct and advantageous characteristic of being metabolized to a less lipophilic compound. This results in an improved safety profile. The new compounds have particular utility for treating life- threatening ventricular tachyarrhythmias, especially in patients with congestive heart failure (CHF). The compounds also provide effective management for ventricular arrhythmias and supraventricular arrhythmias, including atrial fibrillation and re-entrant tachyarrhythmias involving accessory pathways.
L'invention concerne de nouveaux composés (et leurs sels), ainsi que des compositions contenant lesdits composés, pour le traitement des arythmies cardiaques. L'invention concerne en outre des méthodes pour la production desdits composés. Ces nouveaux composés sont des analogues rapidement métabolisés de l'amiodarone, présentant l'avantage d'être métabolisés en un composé moins lipophile et constituant par conséquent un moyen de traitement plus sûr que l'amiodarone. Ces nouveaux composés sont particulièrement utiles pour le traitement de la tachycardie ventriculaire, constituant un danger de mort, en particulier chez des patients souffrant d'une insuffisance cardiaque congestive. Ces composés permettent également une maîtrise efficace des arythmies ventriculaires et supraventiculaires, telles que la fibrillation atriale et les tachycardies par réentrée affectant les voies accessoires.
Druzgala Pascal
Aryx Therapeutics
Mbm Intellectual Property Law Llp
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