A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/155 (2006.01) A61K 31/18 (2006.01) A61K 31/381 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/444 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2506948
The invention relates to a pharmaceutical formulation comprising a LTB4 antagonist having a hydroxy and a benzamidine group or a tautomer, a pharmaceutically acceptable salt or solvate thereof, in particular a compound of formula (I), wherein R and A are as defined in the claims, or a tautomer, a pharmaceutically acceptable salt or solvate thereof (1) and at least one cyclooxygenase-2 inhibitor, a combined cox1/2 inhibitor or a pharmaceutically acceptable salt or solvate thereof (2), and a pharmaceutically acceptable carrier or excipient, and optionally one or more other therapeutic ingredients.
La présente invention a trait à une préparation pharmaceutique comportant un antagoniste LTB¿4? présentant un groupe hydroxy et un groupe benzamidine ou un tautomère, un sel ou solvate pharmaceutiquement acceptable de celui-ci, notamment un composé de formule (I), dans laquelle : R et A sont tels que définis dans les revendications, ou un tautomère, un sel ou solvate pharmaceutiquement acceptable de celui-ci (1) et un moins un inhibiteur de la cyclooxygénase-2, un inhibiteur de cox 1/2 combiné ou un sel ou solvate pharmaceutiquement acceptable de celui-ci (2), et un support ou excipient pharmaceutiquement acceptable, et éventuellement un ou plusieurs agents thérapeutiques.
Birke Franz
Jennewein Hans Michael
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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