C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01)
Patent
CA 2526398
Isolated human monoclonal antibodies which bind to Anthrax protective antigen 035 disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. A1so disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
L'invention concerne des anticorps monoclonaux humains isolés se fixant sur un antigène protecteur de l'anthrax. Ces anticorps humains peuvent être produits dans un animal transgénique non humain, une souris transgénique par exemple, capable de produire des isotypes multiples d'anticorps monoclonaux humains lorsqu'il est soumis à une recombinaison VDJ et à une commutation isotypique. L'invention concerne également des dérivés d'anticorps humains (des anticorps bispécifiques et des immunoconjugués, par exemple), des compositions pharmaceutiques contenant lesdits anticorps humains, des animaux transgéniques non humains et des hybridomes produisant ces anticorps, ainsi que des méthodes thérapeutiques et diagnostiques utilisant lesdits anticorps humains.
Blanset Diann
Keler Tibor
Lowy Israel
Srinivasan Mohan
Vitale Laura A.
Borden Ladner Gervais Llp
Medarex Inc.
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