Pyridine [3,4-b] pyrazinones as pde-5 inhibitors

Details Pyridine [3,4-b] pyrazinones as pde-5 inhibitors Pyridine [3,4-b] pyrazinones as pde-5 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4985 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2608672

Compounds, tautomers of the compounds, and pharmaceutically acceptable salts of the compounds or tautomers are disclosed, wherein the compounds have the structure of Formula I: wherein R2, X6, Y6, R6, and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

Cette invention concerne des composés, des tautomères de ces composés, et des sels pharmaceutiquement acceptables de ces composés ou tautomères. Ces composés possèdent une structure représentée par la formule (I), dans laquelle R2, X6, Y6, R6 et R8 sont définis dans les pièces descriptives de la demande. Des compositions pharmaceutiques correspondantes, des procédés de traitement, des procédés de synthèse et des intermédiaires sont également divulgués.

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