G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2635833
The present invention relates to a method for determining a risk whether an individual will suffer from a cardiovascular adverse event as a consequence of cardiac stress testing, comprising the steps of (a) measuring, preferably in vitro, the level of Placenta Growth Factor, wherein (b) if the level of the Placenta Growth Factor is at least increased, then the individual is at least at risk of suffering from an adverse event as a consequence of cardiac stress testing. In a further embodiment, additionally another marker is measured, particularly a natriuretic peptide, most particularly NT-proBNP. The present invention allows to stratify patients according to the environment and conditions under which cardiac stress testing should be carried out.
La présente invention concerne un procédé de détermination du risque qu'un individu subisse un événement cardiovasculaire indésirable suite à une épreuve d'effort cardiaque, comprenant (a) la mesure, de préférence in vitro, du taux de facteur de croissance placentaire ; (b) si le taux de facteur de croissance placentaire est au moins augmenté, l'individu risque de subir un événement indésirable suite à l'épreuve d'effort cardiaque. Selon un autre mode de réalisation, on mesure en plus un autre marqueur, en particulier un peptide natriurétique, plus particulièrement le NT-proBNP. La présente invention permet d'évaluer les patients en fonction de l'environnement et des conditions dans lesquelles l'épreuve d'effort cardiaque doit avoir lieu.
Hess Georg
Horsch Andrea
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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