Therapeutic antibody against muc-1 antigen and methods for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2380936

The invention provides therapeutic compositions comprising binding agents that specifically bind to tumor-associated MUC-1 and reduce, reverse or prevent their effects in cancer. More particularly, the invention provides therapeutic compositions that comprise a binding agent that can specifically bind to an epitope that comprises both peptide and carbohydrate on such tumor-associated MUC-1. The invention further provides methods for the use of such therapeutic compositions in the treatment of cancer.

La présente invention concerne des compositions thérapeutiques comprenant des agents de liaison qui se lient spécifiquement aux MUC-1 associés à une tumeur et permette de réduire, d'inverser ou de prévenir leurs effets en cas de cancer. Plus particulièrement, l'invention concerne des compositions thérapeutiques qui comprennent un agent de liaison qui peut se lier spécifiquement à un épitope comprenant à la fois polypeptide et carbohydrate sur de tels MUC-1 associés à une tumeur. Cette invention concerne également des procédés d'utilisation de compositions thérapeutiques de ce type dans le cadre du traitement du cancer.

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