Substituted bicyclic and tricyclic thrombin receptor...

Details Substituted bicyclic and tricyclic thrombin receptor... Substituted bicyclic and tricyclic thrombin receptor...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/443 (2006.01) A61P 7/02 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2655720

Substituted bicyclic and tricyclic modified himbacine derivative of the formula (I) : or a pharmaceutically acceptable salt or solvate of said compound wherein (DU) represents an optional double bond and wherein En, Fn, Gn, Zn, Jn, X, R3, R9, R10, R11, R32, R33, B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed.

La présente invention concerne un dérivé d'himbacine modifié bicyclique et tricyclique substitué, de formule générale (I) : ou un sel ou solvate de ce composé, acceptable d'un point de vue pharmaceutique. (DU) représente une éventuelle double liaison et En, Fn, Gn, Zn, Jn, X, R3, R9, R10, R11, R32, R33, B et Het sont tels que définis dans cette invention. Cette invention concerne également des compositions pharmaceutiques contenant lesdits composés, un procédé de traitement de maladies associées à une thrombose, une athérosclérose, une resténose, une hypertension, une angine de poitrine, une arythmie, une insuffisance cardiaque et un cancer, lequel procédé consiste à administrer lesdits composés, ainsi qu'une thérapie combinée avec d'autres agents.

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