Antibody molecules having specificity for human il-1.beta.

Details Antibody molecules having specificity for human il-1.beta. Antibody molecules having specificity for human il-1.beta.

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 29/00 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2515474

The invention relates to an ahumanized antibody molecule having specificity for antigenic determinants of IL-1.beta., andwhich is made with CDRs from the murine antibody IC8 that are grafted into human frameworks. Methods for generating genes for grated sequence are also disclosed.

L'invention concerne une molécule d'anticorps possédant une spécificité pour des déterminants antigéniques de IL-1?, des utilisations thérapeutiques de la molécule d'anticorps et des procédés de production de celle-ci.

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