Spirohydantoin aryl cgrp receptor antagonists

Details Spirohydantoin aryl cgrp receptor antagonists Spirohydantoin aryl cgrp receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/4184 (2006.01) A61K 31/424 (2006.01) A61K 31/473 (2006.01) A61P 25/06 (2006.01) C07D 487/10 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2629406

Compounds of formula (I); (wherein variables A1, A2. A3, A4, A5, A6, A7, B3 E1, E2, E3, E4, E5, G1, G2 and R.6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

Cette invention concerne des composés représentés par la formule (I); (dont des variables A1, A2. A3, A4, A5, A6, A7, B3, E1, E2, E3, E4, E5, G1, G2 et R.6 sont explicitées dans le descriptif) qui sont des antagonistes des récepteurs du peptide lié au gène de la calcitonine (Calcitonin Gene-related peptide/ CGRP) qui sont des antagonistes des récepteurs de CGRP et qui conviennent pour le traitement ou la prévention de maladie dans lesquels est impliqué le CGPR, telles que la migraine. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, l'utilisation desdits composés et compositions pour la prévention et le traitement de telles maladies dans lesquelles est impliqué le CGRP.

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