Method for cancer diagnostics

Details Method for cancer diagnostics Method for cancer diagnostics

G - Physics

01

N

G01N 33/574 (2006.01) C12Q 1/02 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2435210

The invention is a method that allows the detection of cancer cells in a cell or tissue sample. One step in the invention is the determination of whether there are cells in the S- or G2-phases of the cell cycle in the sample that contain "cyclin E-type-protein". The method is based on a determination of the level of "cyclin E-type-protein" in the individual cells in the sample together with a determination of the level of a "post G1-substance", i.e. a substance present exclusively in S and/or G2 cells. The sample can be assumed to contain cancer cells if "cyclin E-type-protein" is found in cells in S and/or G2. A high percentage of cells containing "cyclin E-type-protein" in S and/or G2 is an indication that the tumour cells are highly malignant.

L'invention concerne un procédé de détection de cellules cancéreuses dans un prélèvement de cellules ou de tissu. Une étape de l'invention consiste à déterminer si le prélèvement présente des cellules, dans les phases S ou G¿2? du cycle cellulaire, qui contiennent la <= protéine de type cycline E>=. Ce procédé est basé sur la détermination du niveau de <= protéine de type cycline E >= dans les différentes cellules du prélèvement ainsi que la détermination du niveau de <=post-substance G¿1? >=, notamment une substance présente exclusivement dans les cellules S et/ou G2. On peut considérer que le prélèvement contient des cellules cancéreuses si on décèle la <= protéine de type cycline E>= dans les cellules S et/ouG¿2?. Un fort pourcentage de cellules contenant la <=protéine de type cycline E >= dans S et/ou G¿2? indique que les cellules tumorales sont fortement malignes.

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