Migrastatin analog compositions and uses thereof

Details Migrastatin analog compositions and uses thereof Migrastatin analog compositions and uses thereof

A - Human Necessities

61

K

A61K 31/365 (2006.01) A61K 31/075 (2006.01) A61K 31/122 (2006.01) A61K 31/395 (2006.01) A61K 31/45 (2006.01) A61K 31/4523 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2520377

In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-RC, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Un aspect de l'invention concerne des compositions pharmaceutiques comprenant une quantité acceptable d'un point de vue thérapeutique d'un composé de formule (I) dans laquelle R¿1?-R¿6?, R¿a?-R<SB>C</SB>, Q, Y¿1?, Y¿2? et n sont tels que définis dans le texte, la composition étant formulée par administration à une personne selon un dosage compris entre environ 0,1 et environ 50 mg/kg de sa masse corporelle. Un autre aspect de l'invention concerne un procédé pour traiter des métastases de tumeur du sein chez une personne, comprenant l'administration à la personne qui en a besoin, d'une quantité efficace d'un point de vue thérapeutique d'une composition de l'invention telle que décrite ci-dessus et d'une substance de support, d'un adjuvant ou d'un excipient acceptable d'un point de vue pharmaceutique.

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