1,5-diaryl substituted pyrazoles as p38 kinase inhibitors

Details 1,5-diaryl substituted pyrazoles as p38 kinase inhibitors 1,5-diaryl substituted pyrazoles as p38 kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2331878

The present invention contemplates 1,5-diaryl-substituted pyrazole compounds which correspond in structure to Formula (I), or a pharmaceutically-acceptable salt thereof: wherein A is =N- or =CH-; and which inter alia, inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the preparation of the contemplated compounds and for the use of a contemplated compound in treating a mammalian host having a p38 kinase- or TNF- mediated disease.

Cette invention, qui a trait à des composés de pyrazole à substitution 1,5-diaryle, représentés par la formule (I) dans laquelle A représente =N ou =CH-, concerne également un sel de ces composés, acceptable du point de vue pharmaceutique. Ces composés, entre autres effets, inhibent l'activité de la protéine-kinase associée aux membranes, en l'occurrence la protéine p38. Elle porte également sur des procédés de préparation de ces composés ainsi que sur l'utilisation qui est faite de l'un deux pour traiter un mammifère atteint d'une maladie liée à la p38 kinase ou au facteur de nécrose tumorale.

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