Sgip peptides

Details Sgip peptides Sgip peptides

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/22 (2006.01) C07K 14/47 (2006.01) C07K 14/63 (2006.01) C07K 16/26 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2377721

The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.

La présente invention concerne des polynucléotides, des polypeptides, des peptides, des variants et les utilisations de ces derniers pour de nouveaux fragments peptidiques présentant une homologie à la motiline. La distribution tissulaire de l'ARNm pour le nouveau fragment peptidique est spécifique à l'estomac, l'intestin grêle et le pancréas. La liaison du fragment peptidique a été trouvée dans le rein et l'intestin grêle. La présente invention concerne également des agonistes, des antagonistes, des variants, des anticorps et des cellules hôtes exprimant l'ADNc codant le nouveau peptide SGIP.

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