Method and composition for modulating amyloidosis

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/00 (2006.01) A61K 31/138 (2006.01) A61K 31/277 (2006.01) A61K 31/352 (2006.01) A61K 31/4045 (2006.01) A61K 31/407 (2006.01) A61K 31/436 (2006.01) A61K 31/439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/4706 (2006.01) A61K 31/473 (2006.01) A61K 31/475 (2006.01) A61K 31/49 (2006.01) A61K 31/496 (2006.01) A61K 31/53 (2006.01) A61K 31/5415 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2348019

Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that modulation of amyloid deposition occurs. Methods also include administering an effective amount of at least one ABC transporter blocker, or a pharmaceutically acceptable salt thereof, to a subject such that a disease state associated with amyloidosis is treated. Packaged pharmaceutical compositions for treating amyloidosis are described. The package includes a container for holding an effective amount of a pharmaceutical composition and instructions for using the pharmaceutical composition for treatment of amyloidosis. The pharmaceutical composition includes at least one ABC blocker for modulating amyloid deposition in a subject. Methods for identifying agents which modulate amyloid deposition in a subject are also described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to an organism, such that modulation of amyloid deposition occurs.

L'invention concerne des procédés de modulation de l'amylose chez un sujet. Une dose efficace d'au moins un bloqueur de transporteur de cassette de fixation ATP (ABC) est administrée à un sujet, de sorte que la modulation de l'amylose soit induite. Des procédés consistent également à administrer à un sujet une dose efficace d'au moins un bloqueur de transporteur d'ABC, ou un sel de celui-ci, acceptable au plan pharmaceutique, de manière que l'état pathologique associé à l'amylose soit traité. Des compostions pharmaceutiques conditionnées pour le traitement de l'amylose sont également décrites. Le conditionnement est constitué d'un récipient destiné à contenir une quantité efficace d'une composition pharmaceutique et d'instructions d'utilisation de la composition pharmaceutique pour le traitement de l'amylose. La composition pharmaceutique comprend au moins un bloqueur ABC pour la modulation de l'amylose chez un sujet. Des procédés d'identification d'agents qui modulent l'amylose chez un sujet sont également décrits. Une quantité efficace d'au moins un bloqueur de transporteur de cassette de fixation ATP (ABC) est administrée à un organisme, de sorte que la modulation de l'amylose soit induite.

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