A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/42 (2006.01) A61P 25/04 (2006.01) C07C 311/51 (2006.01) C07D 261/08 (2006.01)
Patent
CA 2551523
Compounds having the structure MgX1X2, wherein X1 is parecoxib anion and X2 is as selected from the group consisting of parecoxib anion, chloride, bromide, sulfate, phosphate, nitrate, acetate, propionate, succinate, glycolate, stearate, lactate, malate, tartrate, citrate, ascorbate, glutamate, benzoate, salicylate, methanesulfonate, and toluenesulfonate are disclosed; also disclosed are compounds having the strucure MX1(X2)n wherein M is a metal cation selected from the group consisting of Ca2+, Zn2+, and K+; X1 is parecoxid anion; X2 is selected from the group consisting of parecoxid anion and another pharmaceutically acceptable anion; and n is 0 when M is K+ and n is 1 when M is Ca2+ or Zn2+; Compositions of the invention are useful treatment and prevention of a very wide range of disorders mediated by COX-2, including inflammation, pain and/or fever.
L'invention porte sur des composés de structure MgX?1¿X?2¿, dans laquelle: X?1¿ est un anion de parécoxibe, et X?2¿ est sélectionné parmi: un anion de parécoxibe, un chlorure, un bromure, un sulfate, un phosphate, un nitrate, un acétate, un propionate, un succinate, un glycolate, un stéarate, un lactate, un malate, un tartrate, un citrate, un ascorbate, un glutamate, un benzoate, un salicylate, un méthanesulfonate, et un toluènesulfonate. L'invention porte également sur des composés de structure MX?1¿(X?2¿)¿n? dans laquelle: M est un cation de métal sélectionné parmi Ca?2+¿, Zn?2+¿, et K?+¿; X?1¿ est un anion de parécoxide; X?2¿ est sélectionné parmi un anion de parécoxide et un autre anion pharmacocompatible et n est 0 quand M est K?+¿ et n est 1 quand M est Ca?2+ ¿ou Zn?2+¿. Les préparations de l'invention s'avèrent utiles pour le traitement et la prévention d'un très large éventail de troubles médiés par le COX-2, dont les inflammations, la douleur et/ou la fièvre.
Pharmacia Corporation
Smart & Biggar
LandOfFree
Metal salts of parecoxib as prodrugs of the cox-2 inhibitor... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Metal salts of parecoxib as prodrugs of the cox-2 inhibitor..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Metal salts of parecoxib as prodrugs of the cox-2 inhibitor... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1605654