Method of site-specific alteration of rna and production of...

Details Method of site-specific alteration of rna and production of... Method of site-specific alteration of rna and production of...

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07H 21/02 (2006.01) C12N 15/11 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2076037

2076037 9112323 PCTABS00006 A method of site-directed alteration (removal or removal followed by replacement) of selected nucleotides in an RNA molecule, as well as to mixed phosphate backbone oligonucleotides useful in the method. It further relates to a method of producing polypeptides or proteins encoded by the RNA molecule altered by the present method. Through use of the present method, site-directed cleavage of an RNA molecule is effected, followed by excision of the selected or target segment of the RNA molecule.

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