Variant dimers for receptor activation

Details Variant dimers for receptor activation Variant dimers for receptor activation

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/435 (2006.01) C07K 14/475 (2006.01) C07K 14/71 (2006.01) C07K 14/715 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2117893

2117893 9323550 PCTABS00028 The invention concerns a method for activating receptors selected from receptor tyrosine kinases, cytokine receptors and members of the nerve growth factor receptor superfamily. A conjugate comprising the direct fusion of at least two ligands capable of binding to the receptor(s) to be activated is contacted with the receptors, whereby the ligands bind their respective receptors inducing receptor oligomerization.

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