Cationic lipids

Details Cationic lipids Cationic lipids

C - Chemistry, Metallurgy

07

C

C07C 233/18 (2006.01) A61K 9/127 (2006.01) A61K 47/48 (2006.01) C07C 233/20 (2006.01) C07C 237/22 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2702862

This invention relates to cationic lipids. More particularly the invention relates to biodegradable cationic lipids having a plurality of cationic headgroups and one or more lipophilic tail groups. The lipids are of utility in various applications, and in particular in permitting transfection of molecules, and in particular DNA and RNA, into cells. As such the lipids have specific utility in the field of gene therapy as well as other applications such as delivery of small molecules into cells, detergents, and metal ion complexation for medical or industrial applications.

Cette invention porte sur des lipides cationiques. Plus particulièrement, l'invention porte sur des lipides cationiques biodégradables ayant une pluralité de groupes de tête cationiques et un ou plusieurs groupes de queue lipophiles. Les lipides ont une utilité dans diverses applications et en particulier pour permettre la transfection de molécules, notamment d'ADN et d'ARN, dans des cellules. Comme tels, les lipides ont une utilité spécifique dans le domaine de la thérapie génique ainsi que d'autres applications telles que l'introduction de petites molécules dans des cellules, les détergents et la complexation d'ions métalliques pour des applications médicales ou industrielles.

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