Inhibitors of rotamase enzyme activity

Details Inhibitors of rotamase enzyme activity Inhibitors of rotamase enzyme activity

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/4353 (2006.01) A61K 31/436 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/453 (2006.01) A61K 31/4535 (2006.01) A61K 31/4545 (2006.01) A61K 31/5025 (2006.01) A61K 38/05 (2006.01) A61K 38/12 (2006.01) A61K 38/18 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2206824

This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.

La présente invention concerne le procédé permettant d'utiliser des composés dérivés de l'acide pipécolique neurotrophique ayant une affinité pour les immunophillines de type FKBP comme inhibiteurs de l'activité enzymatique associée aux protéines d'immunophillines, et notamment comme inhibiteurs de l'activité enzymatique de la peptidyl-prolyl isomérase ou de la rotamase pour stimuler ou renforcer la croissance ou la régénération neuronales.

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