Proline compounds as ns3-serine protease inhibitors for use...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 403/12 (2006.01) A61K 38/55 (2006.01) A61P 31/12 (2006.01) C07D 207/16 (2006.01) C07D 207/27 (2006.01) C07D 209/08 (2006.01) C07D 209/42 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/70 (2006.01) C07D 213/75 (2006.01) C07D 217/26 (2006.01) C07D 233/68 (2006.01) C07D 243/12 (2006.01) C07D 253/06 (2006.01) C07D 271/06 (2006.01) C07D 277/06 (2006.01) C07D 277/46 (2006.01) C07D 277/56 (2006.01) C07D 295/15 (2006.01) C07D 307/68 (2006.01) C07D 317/58 (2006.01) C07D 335/10 (2006.01) C07D 401

Patent

CA 2473070

The present invention discloses novel compounds of Formula I which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

La présente invention concerne de nouveaux composés représentés par la formule I, présentant une activité d'inhibition de la protéase du VHC, ainsi que des méthodes de préparation de ces composés. Dans un autre mode de réalisation, l'invention concerne des compositions pharmaceutiques comprenant de tels composés ainsi que des méthodes d'utilisation de ceux-ci dans le traitement des troubles associés à la protéase du VHC.

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