A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C12N 15/113 (2010.01) C12N 15/115 (2010.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07H 21/00 (2006.01) C07K 14/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2695385
The present invention discloses compositions which induce cross-activation of immune mediated and direct death signaling in targeted cells by exploiting the properties of a antibody/peptide- nucleic acid conjugate. The conjugate is able to si-multaneously activate multiple death signaling mechanisms. Methods of using the conjugate of the present invention as an im-munotherapeutic modality for the treatment or prevention of infectious disease, neoplastic diseases or other disorders.
L'invention concerne des compositions qui induisent une activation croisée de la signalisation de la mort médiée par le système immunitaire et directe dans des cellules ciblées par l'exploitation des propriétés d'un conjugué anticorps/acide nucléique de polypeptide. Le conjugué est capable d'activer simultanément plusieurs mécanismes de signalisation de mort. La présente invention concerne également des procédés d'utilisation du conjugué comme modalité immunothérapeutique pour le traitement ou la prévention de maladies infectieuses, de maladies néoplasiques ou d'autres troubles.
Bedi Atul
Li Shulin
Ravi Rajani
Mbm Intellectual Property Law Llp
The Board Of Supervisors Of Louisiana State University And Agric
The Johns Hopkins University
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