C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 257/06 (2006.01) A61K 31/41 (2006.01) A61K 31/454 (2006.01) A61P 3/06 (2006.01) A61P 9/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2645294
Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.
La présente invention concerne des dibenzylamines et leurs dérivés, des compositions pharmaceutiques contenant de tels composés et l'application de tels composés à l'augmentation de certains taux de lipide plasmatique, y compris le choléstérol à lipoprotéine de haute densité, et à la diminution de certaines autres teneurs plasmatiques en lipides, par exemple le cholestérol LDL et les triglycérides, et ainsi au traitement de maladies exacerbées par des teneurs faibles en cholestérol HDL et/ou des teneurs fortes en cholestérol LDL et en triglycérides, par exemple l'athérosclérose et les maladies cardiovasculaires chez certains mammifères, y compris chez l'homme.
Chang George
Garigipati Ravi Shanker
Lefker Bruce Allen
Perry David Austen
Zeng Dongxiang
Pfizer Products Inc.
Smart & Biggar
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