A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/76 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2388807
Methods for treating cell proliferative disorders by administering virus to proliferative cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.
Cette invention se rapporte à des procédés qui servent à traiter les troubles de la prolifération cellulaire en administrant un virus aux cellules prolifératives comportant un chemin ras activé. Le virus est administré de telle sorte qu'il finit par entrer en contact directement avec les cellules prolifératives ayant un chemin ras activé. Ces troubles de la prolifération cellulaire sont notamment les néoplasmes. Le virus est choisi parmi des adénovirus modifiés, des virus HSV modifiés, les virus de la vaccine modifiés et les virus orf du parapoxe modifiés. Cette invention concerne également des procédés servant à traiter les troubles de la prolifération cellulaire en administrant également un agent immunosuppresseur.
Coffey Matthew C.
Thompson Bradley G.
Oncolytics Biotech Inc.
Torys Llp
LandOfFree
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