Quinazoline derivatives

Details Quinazoline derivatives Quinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2538752

The invention concerns quinazoline derivatives of Formula (I): wherein each of R1, X1, R2, R3, R5, n and m have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of EGF and erbB receptor tyrosine kinases.

L'invention concerne des dérivés de quinazoline représentés par la formule I: (I), dans laquelle R1, X1, R2, R3, R5, n et m ont chacun la signification indiquée dans le descriptif, ainsi que des procédés permettant la préparation de ces dérivés, des compositions pharmaceutiques contenant ces dérivés, et l'utilisation de ces dérivés pour la préparation d'un médicament utilisable comme agent antiprolifératif pour la prévention ou le traitement des tumeurs réagissant à l'inhibition des récepteurs à activité tyrosine kinase des facteurs EGF et erbB.

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