Process for the preparation of 4,5,6,7-tetrahydro- thieno...

Details Process for the preparation of 4,5,6,7-tetrahydro- thieno... Process for the preparation of 4,5,6,7-tetrahydro- thieno...

C - Chemistry, Metallurgy

07

D

260/276.1

C07D 471/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1087187

Process for the preparation of 4,5,6,7-tetrahydro-thieno[2,3-c]- and [3,2-c]pyridines ABSTRACT OF THE DISCLOSURE This invention relates to a process for the preparation of 4,5,6,7-tetrahydro-thieno[2,3-c]- and [3,2-c]pyridines having the formulae: Image (I) and Image (II) in which R1 is selected from hydrogen and halogen; R2 is selected from hydrogen and hydroxy; R3 and R4, which may be the same or different, are each selected from hydrogen, C1-6 alkyl, phenyl- alkyl having 1-6 carbon atoms in the alkyl moiety, and phenyl- C1-6alkyl substituted on the phenyl nucleus with at least a substituent selected from halogen, C1-6 alkyl, C1-6 alkoxy, hydroxy, nitro, cyano and trifluoromethyl; and their acid addi- tion salts. Said derivatives possess therapeutically useful anti-sludge, anti-thrombosis and blood-platelet aggregation inhibiting properties. - 1 -

294348

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