Heterocyclic tripeptides as hepatitis c inhibitors

Details Heterocyclic tripeptides as hepatitis c inhibitors Heterocyclic tripeptides as hepatitis c inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/47 (2006.01) A61P 31/00 (2006.01) C07K 4/00 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2474031

Compounds of formula (I):wherein R1 is hydroxyl or sulfonamide derivative; R2 is t-butyl or -CH2-C(CH3)3 or -CH2-cyclopentyl; R3is t-butyl or cyclohexil and R4 is cyclobutyl, cyclopentyl or cyclohexyl; or a pharmaceutically acceptable salt thereof, are described as useful as inhibitor of the HCV NS3 protease.

La présente invention concerne des composés représentés par la formule (I). Dans la formule, R?1¿ représente un dérivé hydroxyle ou sulfonamide; R?2¿ représente t-butyle ou CH¿2?-C(CH¿3?)¿3? ou CH¿2?-cyclopentyle; R¿3? représente t-butyle ou cyclohexyle et R?4¿ représente cyclobutyle, cyclopentyle ou cyclohexyle. Ces composés ou un sel pharmaceutiquement acceptable de ces derniers sont utiles en tant qu'inhibiteurs de la protéase de protéines non structurelles NS3 du virus de l'hépatite C (VHC). Formule (I)

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