Hybrid factor viii with modified activity

Details Hybrid factor viii with modified activity Hybrid factor viii with modified activity

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/36 (2006.01) A61K 38/48 (2006.01) A61K 38/55 (2006.01) A61K 48/00 (2006.01) C07K 14/745 (2006.01) C07K 14/81 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01) C12N 9/96 (2006.01) C12N 15/12 (2006.01) C12N 15/15 (2006.01) C12N 15/57 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2235628

Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifiying the properties of proteins; and treatment methods employing hybrid proteins.

Des protéines hybrides agissant sur la coagulation sanguine comprennent une région provenant d'une protéine donneuse anticoagulante ou antithrombotique, et la protéine hybride résultante possède une activité biologique modifiée. Des informations concernant ces protéines hybrides impliquent un codage, à l'aide de séquences d'ADN, des protéines et des hôtes, notamment des animaux transgéniques, qui possèdent ces séquences d'ADN. On décrit également des anticorps dirigés contre ces protéines hybrides, des procédés de modification des propriétés de ces protéines, ainsi que des méthodes de traitement dans lesquelles on utilise ces protéines hybrides.

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