Sustained release film preparation for local administration...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/5575 (2006.01) A61K 9/70 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 27/14 (2006.01) A61L 27/54 (2006.01) A61L 27/58 (2006.01) A61P 1/02 (2006.01) A61P 3/14 (2006.01) A61P 19/00 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2467061

A persistent filmy preparation which comprises methyl (11.alpha.,13E,15.alpha.)-9-oxo-11,15-dihydroxy-16-(3-methoxymethylphenyl)- 17,18,19,20-tetranor-5-thiaprost-13-enoate represented by the formula (I): (I) or a nontoxic salt thereof as an active ingredient and a bioabsorbable polymer as a substrate and which is for use in topical administration to a sick location where the bone amount is small; and a remedy for bone amount reduction which comprises the persistent filmy preparation. The persistent filmy preparation, which contains the compound (I) as an active ingredient, promotes bone formation upon topical administration and is useful for treatments for bone amount reduction.

Préparation pelliculaire persistante comprenant méthyle (11.alpha., 13E, 15.alpha.)-9-oxo-11,15-dihydroxy-16-(3-méthoxyméthylphényl)-17,18,19,20-tétranor-5-thiaprost-13-énoate représentée par la formule (I), ou un de ses sels non toxique en tant qu'ingrédient actif, et un polymère bioabsorbable en tant que substrat et qui est conçue pour une administration localisée sur une zone présentant une carence en densité osseuse. Remède servant à réduire cette carence et contenant cette préparation. Cette dernière, qui contient le composé (I) en tant qu'ingrédient actif favorise la croissance osseuse lorsqu'on l'administre localement et est utile pour des traitements de régulation de la densité osseuse.

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