Stable liquid form of 5-aminosalicylic acid

A - Human Necessities – 61 – K

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A61K 31/195 (2006.01) A61K 9/00 (2006.01) A61K 31/60 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2016825

Abstract of the Disclosure An aqueous solution of 5-aminosalicylic acid (5-ASA) and a nontoxic alkali, alkali metal or alkaline earth metal salt of 5-aminosalicylic acid having a pH of 3-5 is dis- closed. The sole buffer in the solution is that intrinsic- ally formed by 5-aminosalicylic acid and its alkali, alkali metal or alkaline earth metal salt. The solutions prefer- ably also contain an antioxidant and a metal complexing agent. In preferred practice, the 5-ASA salt is formed in situ by addition of an alkali, alkali metal or alkaline earth metal hydroxide to a solution of 5-ASA. The solution is stable and does not significantly discolor due to 5-ASA decomposition for extended periods of time. MO1529

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