C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/34 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/13 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2097416
2097416 9209613 PCTABS00013 Single chain immunotoxins directed at the human transferrin receptor using PCR based methods are described. Anti-TFR(Fv)-PE40 contains DNA for the antigen binding portion (Fv) of a monoclonal antibody directed at the human transferrin receptor fused to the DNA for a 40,000 molecular weight fragment of Pseudomonas exotoxin (PE40). In another fusion protein, DT388-anti-TFR(Fv), DNA for the antigen binding portions of the anti-TFR antibody has been fused to the DNA encoding a truncated form of Diphtheria toxin. In anti-TFR(Fv)-PE40, the single chain antibody precedes the toxin whereas in DT388-anti-TFR(Fv) the single chain antibody is at the carboxyl end of toxin. The proteins encoded by these gene fusions were expressed in E. coli and purified by conventional chromatographic techniques to near homogeneity.
Batra Janendra
Chaudhary Vijay
Fitzgerald David
Pastan Ira
Swabey Ogilvy Renault
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
LandOfFree
Recombinant immunotoxin composed of a single chain antibody... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Recombinant immunotoxin composed of a single chain antibody..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Recombinant immunotoxin composed of a single chain antibody... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1608474