Novel isoindole derivatives, compositions containing same,...

Details Novel isoindole derivatives, compositions containing same,... Novel isoindole derivatives, compositions containing same,...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2603634

The invention concerns novel products of formula (I), wherein: A1, A2, A3 and A4 represent CRa or N; n represents 1 or 2; R1 represents O, S or NRb; R2 represents H, halogen, CF3, nitro, cyano, methyl, ethyl, hydroxy, mercapto, amino, methoxy, thiomethoxy, methylamino, dimethylamino, acetylamino, carboxy and carboxamido; Ra represents in particular H, halogen, CF3, hydroxy, mercapto, nitro, amino, NH-OH, NH-CO-H, NH-CO-OH, NH-CO-NH2, carboxy, cyano, carboxamido, Y-(CH2)p-alkyl, Y (CH2)p-cycloalkyl, Y-(CH2)p-heterocycloalkyl, Y-(CH2)p-aryl or Y-(CH2)p-heteroaryl, with Y = O, S, NH, O-C(O), C(O)-NH, NH-C(O), NH-S(O) or NH-S(O)2, and p = 1, 2, or 3; Rb represents H, (CH2)m-cycloalkyl, (CH2)m-heterocycloalkyl, (CH2)m-aryl or (CH2)m-heteroaryl, with m = 0, 1, 2; said products being in all isomeric forms and the salts thereof, as medicines.

L'invention concerne les nouveaux produits de formule (I) : dans laquelle A1, A2, A3 et A4 représentent CRa ou N ; n représente 1 ou 2 ; R1 représente O, S ou NRb ; R2 représente H, halogène, CF3, nitro, cyano, méthyle, éthyle, hydroxy, mercapto, amino, méthoxy, thiométhoxy, méthylamino, diméthylamino, acétylamino, carboxy et carboxamido ; Ra représente notamment H, halogène, CF3, hydroxy, mercapto, nitro, amino, NH-OH, NH-CO-H, NH-CO-OH, NH-CO-NH2, carboxy, cyano, carboxamido, Y-(CH2)p-alkyle, Y (CH2)p-cycloalkyle, Y-(CH2)p- hétérocycloalkyle, Y-(CH2)p-aryle ou Y-(CH2)p-hétéroaryle, avec Y = O, S, NH, O-C(O), C(O)-NH, NH-C(O), NH-S(O) ou NH-S(O)2, et p = 1, 2, ou 3 ; Rb représente H, (CH2)m-cycloalkyle, (CH2)m-hétérocycloalkyle, (CH2)m-aryle ou (CH2)m-hétéroaryle, avec m = 0, 1, 2 ; ces produits étant sous toutes les formes isomères et les sels, ô titre de médicaments.

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