Imidazole-containing peptide and preparation therof

Details Imidazole-containing peptide and preparation therof Imidazole-containing peptide and preparation therof

C - Chemistry, Metallurgy

07

D

167/237, 260/314

C07D 233/90 (2006.01) A61K 38/04 (2006.01) C07K 5/02 (2006.01) C07K 5/04 (2006.01) C07K 5/065 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2004434

Abstract of the Disclosure Imidazole-containing Peptide and preparation thereof Imidazole-containing peptide of the formula: Image (I) wherein R1 is a branched alkyl group, a branched alkyloxy group or an aryl-substituted lower alkyloxy group, R2 and R4 are the same or different and each is hydrogen atom or a lower alkyl group, R3 and R5 are a phenyl-substituted lower alkyl group, R6 is hydrogen atom or a lower alkoxycarbonyl group, R7 is hydrogen atom or a nitrogen containing heterocyclic group-substituted lower alkylthio group, X1 and X2 are the same or different and each is -?H-, -O?H- or -?-, A is a lower alkylene group which may be substituted with a substituent selected from the group consisting of a lower alkoxy group, hydroxymethyl group and a group of the formula: Image and R8 and R9 are the same or different and each is hydrogen atom or a lower group, or a pharmaceutically acceptable salt thereof, which is useful as an immunomodulator and as an agent for the treatment and /or prophylaxis of autoimmune diseases such as rheumatoid arthritis, mulripule sclerosis, systemic lupus erthematodes, glomerulonephris, rhumatic fever or type I diabetes and atopic allergy, a processes for the preparation thereof, and a pharmaceutical composition containing said compound as an active ingredient.

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