C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2315263
A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PA153 and transcribed from pancreatic tissue, are described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the pancreas, such as pancreatic cancer. Also provided are antibodies which specifically bind to PA153-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PA153 polypeptide, which molecules are useful for the therapeutic treatment of pancreatic diseases, tumors or metastases.
L'invention concerne une série de séquences d'ADN complémentaire contiguës et se chevauchant en partie, ainsi que des polypeptides codés par ces séquences dénommées PA153 et transcrites à partir de tissu pancréatique. Ces séquences s'utilisent pour la détection, le diagnostic, la stadification, le contrôle, le pronostic, la formation d'images in vivo, la prévention ou le traitement, ou la détermination de la prédisposition d'un individu à des affections et troubles du pancréas tels que le cancer du pancréas. L'invention concerne également des anticorps se liant spécifiquement au polypeptide ou à la protéine codée par PA153, ainsi que des agonistes ou inhibiteurs empêchant l'action du polypeptide PA153 spécifique au tissu, ces molécules s'utilisant pour le traitement thérapeutique de maladies, tumeurs ou métastases du pancréas.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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