C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2224940
Complexes of p53 with the transcription factors DP-1 (and other members of the DP family) or E2F-1 (or other E2F proteins, up to and including E2F-5), are disclosed. These novel complexes can be used to assay for potential chemotherapeutic agents that are p53 agonists or antagonists, particularly agonists or antagonists which modulate progression through the cell cycle by disruption of the normal binding of p53 to DP-1 and/or E2F-1.
L'invention porte sur des complexes comprenant la protéine p53 avec les facteurs de transcription DP-1 (et d'autres membres de la famille DP) ou E2F-1 (ou d'autres protéines E2F, jusqu'à la protéine E2F-5 incluse). Il est possible d'utiliser ces nouveaux complexes dans le cadre d'épreuves concernant des agents chimiothérapeutiques potentiels qui sont des agonistes ou antagonistes de la protéine p53, en particulier des agonistes ou antagonistes modulant une progression d'un bout à l'autre du cycle cellulaire par l'interruption de la fixation normale de la protéine p53 à DP-1 et/ou à E2F-1.
Kirby Eades Gale Baker
Medical Research Council
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