Production of tissue engineered heart valves

Details Production of tissue engineered heart valves Production of tissue engineered heart valves

A - Human Necessities

61

L

A61L 27/38 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2602050

The invention is directed to methods for preparing artificial heart valves by preconditioning a matrix seeded with endothelial cells and smooth muscle cells differentiated from isolated progenitor cells. These cell seeded matrices are exposed to fluid conditions that mimic blood flow through the heart to produce tissue engineered heart valves that are analogous to native heart valves.

L'invention concerne des méthodes destinées à la préparation de valvules cardiaques artificielles, consistant à soumettre une matrice ensemencée par des cellules endothéliales et des cellules des muscles lisses différenciées à partir de cellules souches isolées à un traitement préalable. Ces matrices ensemencées par des cellules sont ensuite exposées à des conditions fluidiques reproduisant l'écoulement sanguin à travers le sang pour produire par génie tissulaire des valvules cardiaques semblables aux valvules cardiaques naturelles.

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