Heterocyclic inhibitors of mek and methods of use thereof

Details Heterocyclic inhibitors of mek and methods of use thereof Heterocyclic inhibitors of mek and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 237/24 (2006.01) C07D 401/06 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2545660

Disclosed are compounds of the Formula (I) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

L'invention concerne des composés de la formule (I) et des sels pharmaceutiquement acceptables et leurs pro-médicaments, R1, R2, R7, R8 et R9, W, X et Y ayant la définition donnée dans la description. De tels composés sont des inhibiteurs de MEK et sont utiles dans le traitement de maladies hyperprolifératives, telles que le cancer et l'inflammation, chez les mammifères, et les états inflammatoires. L'invention concerne des procédés d'utilisation de tels composés pour le traitement de maladies hyperprolifératives chez les mammifères et compositions pharmaceutiques contenant de tels composés.

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