Replication protein a binding transcriptional factor (rbt1)...

Details Replication protein a binding transcriptional factor (rbt1)... Replication protein a binding transcriptional factor (rbt1)...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2377730

The present invention relates to replication protein A (RPA) transcriptional factors. There is provided a nucleotide sequence encoding a replication protein A binding transcriptional activator 1 (RBT1) and a protein encoded by such a nucleotide sequence. RBT1 has a high activity and is highly transactivated in cancer cells. The sequence may be used to treat neoplastic disorders and in gene therapy.

L'invention concerne des facteurs transcriptionnels de protéine de réplication A (RPA). L'invention concerne également une séquence nucléotidique codant pour un activateur transcriptionnel 1 de protéine de réplication A (RBT1), et une protéine codée par la séquence nucléotidique. RBT1 possède une activité élevée, et est hautement transactivé dans les cellules cancéreuses. Il est possible d'utiliser cette séquence pour traiter les troubles néoplasiques et dans une thérapie génique.

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