C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) C07D 207/50 (2006.01)
Patent
CA 2594662
The present invention relates to tricyclic pyrazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
L'invention concerne des pyrazoles tricycliques utiles dans le traitement des maladies prolifératives cellulaires, dans le traitement des troubles associés à l'activité de la kinésine KSP, et dans l'inhibition de la kinésine KSP. L'invention concerne également des compositions contenant ces composés, ainsi que des méthodes d'utilisation de ces compositions dans le traitement du cancer chez des mammifères.
Breslin Michael J.
Coleman Paul J.
Cox Christopher D.
Neilson Lou Anne
Whitman David B.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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