Vegfr-1 antibodies to treat breast cancer

Details Vegfr-1 antibodies to treat breast cancer Vegfr-1 antibodies to treat breast cancer

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 51/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2453474

The present invention is directed to methods of inhibiting tumor cells by administering an antagonist which inhibits the VEGF/VEGFR-1 autocrine loop of tumor cells. Additional antagonists can be added to inhibit endothelial paracrine loop by inhibiting other VEGFRs expressed on endothelial cells, particularly VEGFR-2. Examples of antagonists include antibodies and small molecules. A preferred cancer for treatment is breast cancer.

L'invention concerne des procédés pour inhiber des cellules tumorales par administration d'un antagoniste qui inhibe la boucle autocrine VEGF/VEGFR-1 de cellules tumorales. Il est possible d'ajouter des antagonistes supplémentaires pour inhiber la boucle paracrine endothéliale par inhibition d'autres récepteurs VEGFR exprimés dans des cellules endothéliales, notamment du récepteur VEGFR-2. Des exemples d'antagonistes incluent des anticorps et des petites molécules. Ces anticorps conviennent de préférence au traitement du cancer du sein.

Affiliated with

Also associated with

Rating

Vegfr-1 antibodies to treat breast cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vegfr-1 antibodies to treat breast cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vegfr-1 antibodies to treat breast cancer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1610159