Neuron regeneration

Details Neuron regeneration Neuron regeneration

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2584921

The invention provides a gene silencing molecule, which is adapted to down- regulate expression of a gene encoding a peptide involved with the Rho-A inhibitory pathway. The gene silencing molecule is used to promote neuron survival and axon regeneration in the central nervous system (CNS). The invention also provides compositions and methods of using same to improve neural survival and promote axonal growth.

L'invention concerne une molécule d'extinction génique conçue pour réguler négativement l'expression d'un gène codant pour un peptide impliqué dans la voie inhibitrice de Rho-A. Cette molécule d'extinction génique est utilisée pour promouvoir la survie neuronale et la régénération axonale dans le système nerveux central (SNC). L'invention concerne également des compositions et des méthodes d'utilisation de ces compositions en vue d'améliorer la survie neuronale et de favoriser la croissance axonale.

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