Computational method for predicting the contribution of...

Details Computational method for predicting the contribution of... Computational method for predicting the contribution of...

G - Physics

06

F

G06F 19/18 (2011.01)

Patent

CA 2525231

The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating the contribution of mutations and combinations of mutations to resistance and hyper-susceptibility. The invention allows the design, optimization and assessment of the efficiency of a therapeutic regimen based upon the genotype of the disease affecting a patient.

La présente invention concerne des procédés et des systèmes d'analyse de résistance de médicaments au VIH-1. Plus spécifiquement cette invention concerne des procédés de prévision de résistance de médicament par corrélation d'informations génotypiques avec des profils phénotypiques. Ces procédés permettent l'identification de mutations associées à une résistance primaire et secondaire de médicaments existants ou de nouveaux médicaments et le calcul de la contribution de ces mutations et de combinaisons de mutations à la résistance et à l'hypersensibilité. Cette invention permet la conception, l'optimisation et l'évaluation de l'efficacité d'un régime thérapeutique fondé sur le génotype de la maladie affectant un patient.

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